Key facts about Sildenafil + Tadalafil
- It is a combination medication of two PDE5 inhibitors.
- It is used to treat the symptoms of erectile dysfunction in men; however, this combination is not approved.
- The combination is not approved in the UK, US or Australia; sildenafil and tadalafil on their own are mostly prescription-only medicines there.
- It is usually taken orally with a glass of water.
- Do not combine it with nitrates or other medicines of the same class.
Sildenafil + Tadalafil brands available at Prashi Pharma are listed below.
Sildenafil + Tadalafil brands and prices
| Brand | Strength | Form | Price from | Link |
|---|---|---|---|---|
| Sildalist 100/20 mg Parex Pharma | 100 mg + 20 mg | Tablet | $150.00 90 Tablets | View |
What is Sildenafil + Tadalafil?
Tadalafil + Sildenafil is a combination of two phosphodiesterase type 5 inhibitors, used to address erectile dysfunction in men. Its use is not approved by any regulatory bodies; therefore, this combination should be taken only under the supervision of a health care provider.
How Sildenafil + Tadalafil Works
Sildenafil and tadalafil work by inhibiting an enzyme called phosphodiesterase type 5 (PDE5). This enzyme is responsible for breaking down cyclic guanosine monophosphate (cGMP) in penile tissues. When used together, both medicines inhibit the same enzyme, potentially increasing and prolonging the activity of cGMP. This promotes smooth muscle relaxation, widens penile blood vessels and improves blood flow, which helps men achieve and maintain an erection during sexual stimulation.
What is Sildenafil + Tadalafil Used For?
Sildenafil + Tadalafil is used to treat erectile dysfunction in men. Erectile dysfunction is a common sexual dysfunction that is characterized by the persistent inability to get and maintain a firm penile erection during sexual activity. It can significantly affect a man’s self-esteem and confidence and cause relationship problems.
Can You Take Sildenafil and Tadalafil Together?
Yes, you can take Sildenafil and Tadalafil together, but only in some cases where a medical professional might recommend a safe and carefully dosed approach. Taking this combination is not something you should try on your own.
Combining the two under strict medical supervision may offer benefits for some men with severe cases of ED [1].
A 2014 randomized controlled trial involving 180 men with erectile dysfunction compared tadalafil 5 mg daily + sildenafil 50 mg as needed against tadalafil 5 mg daily alone over 12 weeks. The combination group showed greater improvements in erectile function, erection hardness, penetration ability and partner satisfaction, with particularly notable benefits in men with severe ED or a poor response to single-drug therapy [1].
Sildenafil + Tadalafil Strengths and Forms
Sildenafil + tadalafil are available as oral medications. One of the most popular options of this combination medicine is Sildalist 100/20 mg, which contains 100 mg Sildenafil and 20 mg Tadalafil in a single oral dosage form. This formulation brings together two PDE5 inhibitors with different durations of action. The appropriate strength and treatment approach should be determined by a qualified healthcare professional based on individual needs.
How to Take Sildenafil + Tadalafil
Follow these administration guidelines while taking Sildenafil + Tadalafil for optimal results.
- Do not take more than one tablet in 24 hours.
- Always follow all the instructions of your healthcare provider while taking this combination medicine.
- Always check the expiry date of the medicine before taking it.
- Swallow the whole tablet with a glass of water.
- Do not crush, split or break the tablet.
- For this medication to work effectively, sexual stimulation is required.
- Read the leaflet of this medicine before taking it.
Missed dose
There is no risk of missing a dose of Sildenafil + Tadalafil because it is taken only when needed before sexual activity, not on a fixed daily schedule.
Overdose
Taking more than the recommended dose of this combination ED medicine may increase the risk of side effects such as headache, dizziness, low blood pressure, flushing, vision changes, or prolonged painful erection.
Seek emergency medical help if you think you have taken too much.
- USCall 911
- UKNHS 111 or 999
- AU13 11 26 Poisons Information or 000
Side Effects of Sildenafil + Tadalafil
Common side effects
- Headache
- Facial flushing
- Nasal congestion
- Indigestion or upset stomach
- Muscle aches
- Back pain
Serious side effects
- Chest pain
- Irregular heartbeat
- Severe dizziness
- Fainting
- Sudden hearing or vision loss
- Prolonged and painful erection
If you experience any serious side effects after taking this medication, seek emergency medical attention.
Who Should Not Take Sildenafil + Tadalafil?
Do not take this combination if you have/are
- Severe cardiovascular disease
- Low or uncontrolled high blood pressure
- Women or children under 18 years of age
- Taking nitrate medicines or riociguat
Talk to your doctor first if you have
- Kidney or liver impairment
- Bleeding disorders or stomach ulcers
- Penile deformity or conditions increasing the risk of prolonged erection
Taking Sildenafil + Tadalafil with Other Medicines, Food and Alcohol
Never take this combination with nitrates (such as glyceryl trinitrate or isosorbide, often used for chest pain) or riociguat. Together they can cause a dangerous drop in blood pressure.
Combining Sildenafil + Tadalafil with certain other groups of medication can lead to side effects or lower the effectiveness of either drug. Some of these medications are:
- Antifungal medications
- Blood pressure medicines
- Anti-seizure medicines
- HIV protease inhibitors
Food
Avoid grapefruit and its juice with this combination ED treatment, as they may increase sildenafil and tadalafil levels in the body, leading to stronger side effects.
Alcohol
Do not combine alcohol with this medication, as it can cause headache, dizziness, flushing and low blood pressure.
Before starting this medication, inform your doctor about any existing health conditions and all medicines you are currently taking.
Sildenafil Vs Tadalafil: What are the Differences?
Although Sildenafil and Tadalafil belong to the same class of medication and work similarly by improving blood flow to the penis, they differ in their onset of action and how long their effectiveness lasts. The table below highlights the main differences between these PDE5 inhibitors.
| Main differences | Sildenafil | Tadalafil |
|---|---|---|
| Onset of action | 30-60 minutes | 30 minutes - 2 hours |
| Duration of action | 4-6 hours | Up to 36 hours |
| Food effect | Onset slowed by heavy meals | Onset not affected by food |
| Brand name | Viagra | Cialis |
Sildenafil + Tadalafil in the US, UK and Australia
United States
- Brand names
- No FDA-approved combination brand
- How it is supplied
- Not approved as a combination
- Regulator
- FDA
United Kingdom
- Brand names
- No MHRA-licensed combination brand
- How it is supplied
- Not approved as a combination
- Regulator
- MHRA
Australia
- Brand names
- No TGA-approved combination brand
- How it is supplied
- Not approved as a combination
- Regulator
- TGA
How to Order Sildenafil + Tadalafil Online With a Prescription
Prashi Pharma is an online pharmaceutical supply platform that provides access to a wide range of medicines, including combination ED treatments such as Sildenafil + Tadalafil. Our platform aims to simplify the medicine-ordering process through an easy-to-use website, secure transactions, and convenient doorstep delivery to supported locations worldwide.
Follow these steps to order medicines with a prescription at Prashi Pharma:
- Browse the available Sildenafil + Tadalafil products and select the brand and strength prescribed by your healthcare professional. Read the product information properly.
- Once you have selected the appropriate medication, add it to your cart. Check the selected strength, quantity, and product details to ensure they match your prescription.
- Proceed to checkout and add your necessary details, including your name, contact number, email address and complete delivery address. Ensure that all information is accurate to avoid delivery delays.
- Upload your prescription from a qualified healthcare professional during checkout, wherever required.
- A registered pharmacist or authorized pharmacy professional will review your prescription and verify the requested medication.
- After successful review of your prescription, your order is dispatched in discreet packaging to maintain the privacy of our customers.
- Once your order has been dispatched, you will receive an email containing a tracking ID which helps you to track the progress of your order until it reaches your delivery address.
How to order · Prescription policy · Shipping policy